Antibiotic-induced population fluctuations and stochastic clearance of bacteria
نویسندگان
چکیده
منابع مشابه
Antibiotic-induced population fluctuations and stochastic clearance of bacteria
Effective antibiotic use that minimizes treatment failures remains a challenge. A better understanding of how bacterial populations respond to antibiotics is necessary. Previous studies of large bacterial populations established the deterministic framework of pharmacodynamics. Here, characterizing the dynamics of population extinction, we demonstrated the stochastic nature of eradicating bacter...
متن کاملAntibiotic resistance shaping multi-level population biology of bacteria
Antibiotics have natural functions, mostly involving cell-to-cell signaling networks. The anthropogenic production of antibiotics, and its release in the microbiosphere results in a disturbance of these networks, antibiotic resistance tending to preserve its integrity. The cost of such adaptation is the emergence and dissemination of antibiotic resistance genes, and of all genetic and cellular ...
متن کاملAntibiotic-induced endotoxin release from bacteria and its clinical significance.
In patients with Gram-negative bacterial infection, the administration of appropriate antibiotics is well recognized as an important chemotherapeutic strategy to reduce morbidity and mortality. The requisite use of antibiotics, however, is thought to contribute, in some cases, to serious side effects such as endotoxin shock, because of the release of biologically active endotoxin from the bacte...
متن کاملLarge fluctuations in stochastic population dynamics: momentum space calculations
Abstract. Momentum-space representation renders an interesting perspective to theory of large fluctuations in populations undergoing Markovian stochastic gain-loss processes. This representation is obtained when the master equation for the probability distribution of the population size is transformed into an evolution equation for the probability generating function. Spectral decomposition the...
متن کاملAnalysis of Noise Induced Stochastic Fluctuations in Gene Regulatory Networks
Stochasticity is well recognized to be of crucial importance in the analysis of gene regulatory problems. This importance stems from the fact that extremely rare but important regulatory molecules often cause a great amount of intrinsic noise within a cell. Such systems are frequently modeled at the mesoscopic level as jump Markov processes, whose probability distributions evolve according to t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: eLife
سال: 2018
ISSN: 2050-084X
DOI: 10.7554/elife.32976